Spero Therapeutics, Inc. Common Stock
Here’s whether Spero Therapeutics, Inc. Common Stock (SPRO) is worth buying in 2026 — based on weekly-updated price trend, RSI momentum, and return vs. the S&P 500. Our current read: Bearish.
Concerns: trading below the 200-day MA (long-term downtrend); below the 50-day MA (medium-term momentum negative); 50-day MA is falling (-7.91% over 10 days); RSI 10 — oversold; weak 1-year return of -49.4%; 3-month momentum negative (-56.6%); rising volume on a downtrend (distribution, 1.58x avg). Currently 61.4% off its 52-week high. Score: -7/7.
SPRO is trading below its 200-day MA ($2.39) — a key warning sign the longer-term trend is under pressure. An RSI of 10.3 has dropped into oversold territory, which has historically preceded short-term bounces. The 1-year return of -49.4% compares to +16.5% for SPY (trailed the market by 65.8%). The current 61.4% drawdown from the 52-week high reflects elevated risk for momentum-based strategies.